Heart failure medicine interactions

The following list shows possible interactions of medicines that are commonly taken together to treat heart failure.

This list does not include every possible interaction, so please tell your health care provider about all the medicines you are taking (prescription, over-the-counter, herbals and vitamins).

You may need other treatments besides medicine to help your heart work better or to prevent serious problems.

Medicine
If taken with May cause these potential effects

Amiodarone (Cordarone®)

digoxin (Lanoxin®)
warfarin (Coumadin®)

increased digoxin effect
increased INR/PT, increased chance for bleeding

Digoxin (Lanoxin®)

antacids that have aluminum
amiodarone (Cordarone®)
diuretic (such as furosemide, hydochlorothiazide)
quinidine

decreased digoxin effect
increased digoxin effect
decreased levels of potassium in your body, which may increase digoxin effect

ACE inhibitors (Captopril®, Enalapril®, Lisinopril®, Quinipril®)

aspirin
ibuprofen (Advil®, Motrin®, Nuprin®)
ketoprofen (Orudis KT®)
naproxen (Aleve®, Naprosyn®)

all have decreased ACE inhibitor effect

Warfarin (Coumadin®)

alcohol
amiodarone (Cordarone®)
aspirin
cimetidine
hydrochlorothiazide
ibuprofen (Advil®, Motrin®, Nuprin®)
ketoprofen (Orudis KT®)
naproxen (Aleve®, Naprosyn®)
quinidine
vitamin K (green, leafy vegetables)

first nine have increased INR/PT, increased chance for bleeding
vitamin K has decreased INR/PT, increased chance for blood clotting